It was the third "No Way Out" event to take place within the WTX Universe. It was SmackDown's first own-brand event of 2016 and was the follow up to January's Royal Rumble event. It was followed by King of the Ring in March.
As with most WTX Universe events, there were 7 matches on the card, 4 of which were for SmackDown's championships. The first match to be set for the event was the World Heavyweight Championship main event that was to see champion Brock Lesnar defend his championship within the Elimination Chamber. Qualifying matches took place throughout the weeks heading into No Way Out seeing superstars Tyler Breeze (who defeated Dolph Ziggler), Neville (who defeated Booker T), Batista (who defeated Kane) and Chris Jericho who defeated the Big Show to set the match. As well as this Samoa Joe was a surprise return entrant, revealed on an episode of SmackDown as he challenged Brock Lesnar in a non-championship losing effort. On the SmackDown prior to No Way Out a 6-Man Tag Team Match took place pitting the smaller superstars involved in the chamber match (Breeze, Neville & Jericho) face the larger superstars, Lesnar, Batista & Joe. The match saw a vicious beatdown on Tyler Breeze, resulting in an injury that removed him from the chamber match. On Main Event the night before No Way Out, a 6-Man Battle Royal took place to determine Breeze's replacement, the match saw former World Champion Christian qualify.
Following Booker T's failed attempt to qualify for the World Heavyweight Championship Match, Booker decided to continue his rivalry with United States Champion, John Cena. Booker took Cena's other rival, Mil Muertes' place in a singles match with Cena on an episode of SmackDown, however Booker once again failed to defeat the champion. SmackDown General Manager Teddy Long decided to give Booker, as well as Mil Muertes another shot at John Cena at No Way Out, adding Dolph Ziggler to the mix as he also failed to qualify for the World Heavyweight Championship Match.
The third championship match to be set saw the Lucha Dragons earn an opportunity at the WWE Tag Team Champions, Luke Harper & Erick Rowan. Following Lucha Dragons' recent success on SmackDown, the team were given a #1 Contenders Match against 3-time champions The Ascension, with Lucha Dragons earning their first shot at tag team championship gold.
The final championship match to be determined came about when under utilized SmackDown diva Alicia Fox picked up an upset victory over the reigning Diva's Champion, Asuka. Due to this, Fox was named #1 Contender, however, due to contreversy from upstarts Alexa Bliss & Emma, who felt they had earned the shot long before Fox, one of the two was given an opportunity that was decided upon themselves, the duo agreed that Bliss would take part in the match.
The three non-championship matches were also set in the prior weeks, a #1 Contenders Match was announced between SmackDown superstars Sami Zayn & Daniel Bryan, who had rarely been featured on SmackDown in recent months. Following his failure to qualify for the World Championship Match, Kane went on to attack and beat Jimmy Uso in singles competition on Main Event. Kane announced big intentions for No Way Out after doing so. Kane then went on to defeated Jey Uso the following week on SmackDown, leading to a Handicap Match between Kane & The Usos being announced for No Way Out. Finally, Bray Wyatt was announced to make his return at No Way Out, going one on one with fellow returning superstar, Diamond Dallas Page.
The event saw only one new champion crowned as Batista won the World Heavyweight Champion, last pinning the former champion Brock Lesnar with a Batista Bomb on the steel.
Alongside the three championship retentions, Sami Zayn was announced #1 Contender following a roll-up on Daniel Bryan.
As a semi-main event, Kane's intentions were revealed as before the announced Handicap Match between Kane & The Uso's could begin, former tag team parnter of Kane, the Big Show, came to Kane's aid, revealing that the team had reunited, the team went on to defeat The Uso's.
|1||Sami Zayn def. Daniel Bryan||Singles Match for #1 Contendership at United States Championship||5:57|
|2||Luke Harper & Erick Rowan (c) def. "Lucha Dragons" Kalisto & Sin Cara||Tag Team Match for WWE Tag Team Championship||7:20|
|3||John Cena (c) def. Dolph Ziggler, Booker T & Mil Muertes||Fatal 4-Way Match for United States Championship||5:54|
|4||Bray Wyatt def. Diamond Dallas Page||Singles Match||6:06|
|5||Big Show & Kane def. The Usos||Tag Team Match||9:13|
|6||Asuka (c) def. Alicia Fox & Alexa Bliss||Triple Threat Match for Diva's Championship||7:44|
|7||Batista def. Brock Lesnar (c), Neville, Chris Jericho, Christian & Samoa Joe||Elimination Chamber Match for World Heavyweight Championship||23:47|
World Heavyweight Championship Eliminations
|Elimination Order||Wrestler||Entered||Eliminated by||Elimination Method||Time|
|1||Samoa Joe||4||Christian||Pinned following Gutbuster||4:50|
|2||Christian||3||Batista||Pinned following Spear||6:58|
|3||Chris Jericho||1||Brock Lesnar||Pinned after being kicked to the mat||13:33|
|4||Neville||2||Brock Lesnar||Pinned after F5||22:09|
|5||Brock Lesnar||6||Batista||Pinned off of Batista Bomb||19:45|